Losartan belongs to a group of medicines known as Angiotensin-II receptor antagonists. Angiotensin-II is a substance produced in your body which binds to receptors in blood vessels, causing them to tighten. This results in an increase in blood pressure. Losartan prevents the binding of Angiotensin-II to these receptors, causing the blood vessels to relax which in turn lowers the blood pressure. Losartan slows the decrease of kidney function in patients with high blood pressure and type 2 diabetes.
Losartan Tablets are used: to treat patients with high blood pressure (hypertension) in adults and in children and adolescents 6-18 years of age.
To protect the kidney in hypertensive type 2 diabetic patients with laboratory evidence of impaired renal function and proteinuria ? 0.5 g per day (a condition in which urine contains an abnormal amount of protein).
To treat patients with chronic heart failure when therapy with specific medicines called angiotensin-convertingenzyme inhibitors (ACE inhibitors, medicine used to lower high blood pressure) is not considered suitable by your doctor. If your heart failure has been stabilised with an ACE inhibitor you should not be switched to losartan.
In patients with high blood pressure and a thickening of the left ventricle, Losartan Tablets have been shown to decrease the risk of stroke (?LIFE indication?).
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