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Valsartan 40mg Capsules, 28 Capsules


Valsartan is used to treat high blood pressure (hypertension) in adults and children who are at least 6 years old. Valsartan is sometimes administered together with other blood pressure medications. Valsartan is also used in adults to treat heart failure and to lower the risk of death after a heart attack. The recommended dose is 80 mg daily. In some cases your doctor may prescribe higher doses (for example 160 mg or 320 mg). You can also combine Valsartan with an additional medicine (for example a diuretic).

About Valsartan Capsules

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Valsartan is used for the treatment of essential hypertension in adults, and hypertension in children and adolescents 6 to 18 years of age.

Valsartan belongs to a class of drugs called angiotensin receptor blockers.

Valsartan is used for variety of condition as per below.

  • Treatment of hypertension, to lower blood pressure. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions (1.1)
  • Treatment of heart failure (NYHA class II-IV); Diovan significantly reduced hospitalization for heart failure (1.2)
  • Reduction of cardiovascular mortality in clinically stable patients with left ventricular failure or left ventricular dysfunction following myocardial infarction (1.3)

How does it work?

Valsartan is a potent and specific angiotensin II (Ang II) receptor antagonist with oral activity. It acts selectively on the AT1 receptor subtype, responsible for the known actions of angiotensin II. Elevated plasma levels of Ang II after the AT1 receptor blockade with valsartan may stimulate the unblocked AT2 receptor, which appears to offset the effect of the AT1 receptor. Valsartan shows no partial agonist activity on the AT1 receptor and shows a much higher affinity (approximately 20,000 times higher) for the AT1 receptor than for the AT2 receptor. Valsartan does not bind or block other hormone receptors or ion channels known to be of importance in cardiovascular regulation.

Valsartan does not inhibit ACE (also known as kininase II) that transforms Ang I to Ang II and breaks down bradykinin. Since there is no effect on ACE and bradykinin and substance P are not potentiated, angiotensin II antagonists are unlikely to be associated with cough. In clinical trials comparing valsartan with an ACE inhibitor, the incidence of dry cough was significantly lower (P <0.05) in patients treated with valsartan than in those treated with an ACE inhibitor (2.6 % vs. 7.9% respectively). In a clinical trial, in patients with a history of dry cough during treatment with an ACE inhibitor, 19.5% of trial subjects who received valsartan and 19.0% of those who received a thiazide diuretic experienced cough. , compared to 68.5% of those treated with the ACE inhibitor (P <0.05).


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